Discover what to do when your body doesn't tolerate levothyroxine or Synthroid. This article breaks down the most reliable prescription and OTC thyroid hormone replacements, the unique risks and benefits of each option, and compares alternatives side by side. You'll find practical tips for navigating treatment changes and what to ask your doctor. Walk away ready to make sense of the confusing world of hypothyroid medication when the classic options aren't working for you.